In 2017 I published an article written about the importance of identifying clostridia bacterial infections. I identified that when an infection is present it can inhibit the function of enzyme dopamine hydroxylase which is critical in converting dopamine to noradrenaline. At the time, the research was limited. However, I was trained about this compromised enzyme by a great mentor of mine, Dr. Woeller. For the last several years I’ve looked for this infection with nearly every client that I’ve worked with. I find the identification of an overgrowth of C.difficile on an organic acids test to be a tremendous healing opportunity with many of my clients. Once interventions are in place, healing begins and symptoms very well improve and in some case absolve. The organic acids test provides this information.
New research has recently surfaced that further supports this inhibition of enzyme dopamine hydroxylase by the presence of clostridium difficil.
“For example, it has been recently shown that C. difficile alters the metabolism of the neurotransmitter dopamine in the mouse brain, thus interfering with those cognitive functions that involve the neuromodulatory action of dopamine, such as motivation and memory consolidation in rodents (Vinithakumari et al., 2022). Thus, C. difficile might exert a control on the brain with a mechanism similar to those one exploited already by other micro-organisms that alter the level of neurotransmitters, for example, Lactococcus bacteria (Strandwitz et al., 2019), Bifidobacterium infantis (Desbonnet et al., 2010), or Toxoplasma gondii (Luder et al., 1999). Moreover, being C. difficile a pathogen synthetizing toxins, the mechanisms that ultimately lead impacting the brain might likely imply those already described for other bacteria which toxins can lead to a proinflammatory state “
The researchers explore further the affect of this dopamine interference on neurodevelopmental disorders and neurodegenerative disorders.
Table – PMC
If you are interested in reviewing how the organic acids test may reveal this overgrowth or infection please refer to this article.
Bringing much light,
Lynn
